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Company Overview

The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe. One of the world's most respected comprehensive centers devoted exclusively to cancer, we have been recognized as one of the top two cancer hospitals in the country by U.S. News & World Report for more than 30 years.

Job Description

We are looking for a post-doctoral research fellow to join our group to develop new methods for functional proteomics and engineered therapeutics of fusion oncoproteins. Fusion oncoproteins contribute to the majority of cancers that affect young people. However, their molecular mechanisms and direct inhibitors are not defined. This project aims to make transformational advances to protein cancer biology, ideally suited for scientists seeking advanced training to prepare them for independent scientific research careers.

Details of our research group are available at http://alexkentsis.net/. Recently, we've used protein engineering and proteomic approaches to develop first-in-class peptidic inhibitors of transcription factor MYB (PMID: 29317678, PMID: 33527899), as well as novel methods in functional proteomics and mass spectrometry (PMID: 28821601, PMID: 31083951, PMID: 33749263). We have now extended these approaches to develop a novel peptide interference screening platform, optimally suited for the study of fusion oncoproteins and development of direct peptidomimetic inhibitors.

As a post-doctoral research fellow, you will leverage an integrated team of researchers using functional proteomics, protein engineering, diverse cell and animal cancer models, and the dynamic intellectual environment of MSK. An ideal candidate is a PhD graduate with experience in biochemistry, protein engineering, or structural biology. Knowledge of cancer biology is preferred.

The ideal candidate should have:

• Excellent communication
• project managements skills are essential
• New ideas and interdisciplinary approaches are encouraged

MSK and Tri-I provide a dynamic, nurturing, and inspiring training environment.

If you have any questions about this job opportunity, please contact:

Contact Name: Alex Kentsis MD, PhD

Contact Email: kentsisresearchgroup+application@gmail.com.

Please include a cover letter, brief statement of prior research experience and research interests, CV, and contact information for three references in your application submission.

Salary: $54,439 - $100,940

Closing

MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.

Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.